Estrella Immunopharma, Inc. DEF 14AProxy Statements

Security Ownership

SECURITY OWNERSHIP OF CERTAIN BENEFICIAL OWNERS AND MANAGEMENT 8 HOUSEHOLDING OF PROXY MATERIALS 10 OTHER MATTERS 11 i End Page 3 Begin Page 4 Anchor TABLE OF CONTENTS ESTRELLA IMMUNOPHARMA, INC. 5858 Horton Street, Suite 370 Emeryville, California 94608 PROXY STATEMENT FOR THE COMBINED 2025/2026 ANNUAL MEETING OF STOCKHOLDERS To Be Held On June 29, 2026 Anchor QUESTIONS AND ANSWERS ABOUT THESE PROXY MATERIALS AND VOTING We are providing you with these proxy materials because the Board of Directors of Estrella Immunopharma, Inc. (the “Board”) is soliciting your proxy to vote at the Combined 2025/2026 Annual Meeting of Stockholders (the “Annual Meeting”) of Estrella Immunopharma, Inc. (the “Company”), including at any adjournments or postponements thereof, to be held on Monday, June 29, 2026 at 10:00 a.m. Eastern Time. The Annual Meeting will be a virtual stockholder meeting through which you can listen to the meeting, submit questions in advance, and vote online. The Annual Meeting can be accessed by visiting www.virtualshareholdermeeting.com/ESLA2026 and entering your 16-digit control number (included on the proxy card mailed to you). There is no physical location for the Annual Meeting. You are invited to attend the Annual Meeting to vote on the proposal described in this Proxy Statement. However, you do not need to attend the Annual Meeting to vote your shares. Instead, you may simply follow the instructions below to submit your proxy. The proxy materials, including this Proxy Statement, are being distributed on or about May 27, 2026. As used in this Proxy Statement, references to “we,” “us,” “our,” “Estrella,” and the “Company” refer to Estrella Immunopharma, Inc. and our consolidated subsidiaries. Why is this meeting called the “Combined 2025/2026 Annual Meeting of Stockholders”? This meeting will serve as the Company’s annual meeting of stockholders for both fiscal year 2025 and fiscal year 2026. Although the meeting is referred to as the “Combined 2025/2026 Annual Meeting of Stockholders,” it is a single meeting of stockholders held in accordance with the Company’s certificate of incorporation and Delaware corporate law. Throughout this Proxy Statement, we refer to it simply as the “Annual Meeting.” Why am I receiving these proxy materials? The Board is providing these proxy materials to you in connection with the solicitation of proxies for use at th